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Krüppel-Like Factor 1: A Pivotal Gene Regulator in Erythropoiesis

29 Sept 2022

Abstract excerpt

Krüppel-like factor 1 (KLF1) plays a crucial role in erythropoiesis. In-depth studies conducted on mice and humans have highlighted its importance in erythroid lineage commitment, terminal erythropoiesis progression and the switching of globin genes from γ to β. The role of KLF1 in haemoglobin switching is exerted by the direct activation of β-globin gene and by the silencing of γ-globin through activation of...

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PMID: 36231031
DOI: 10.3390/cells11193069

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