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Article

Ribosome mutants with altered accuracy translate with reduced processivity.

Journal of molecular biology - 5 May 1995

Dong H, Kurland C G

Abstract excerpt

We have determined whether or not there is a correlation between the accuracy of tRNA selection and the processivity of translation by mutant ribosomes. In our assay the estimation of processivity was made from a system in which transcription is dependent on T7 RNA polymerase in order to eliminate the influence of transcriptional polarity on our measurements. We found that the processivity of translation is...

Topics

DNA-Directed RNA Polymerases
Drug Resistance, Microbial
Escherichia coli
Kinetics
Mutation
Protein Biosynthesis
Protein Conformation
RNA, Messenger
RNA, Transfer, Amino Acyl
Ribosomal Proteins
Ribosomes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Streptomycin

Suppression, Genetic

Viral Proteins

beta-Galactosidase

Source

Identifiers

PMID: 7752224
DOI: 10.1006/jmbi.1995.0242

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7752224-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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