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Article

Codon usage influences fitness through RNA toxicity.

Proceedings of the National Academy of Sciences of the United States of America - 21 Aug 2018

Mittal Pragya, Brindle James, Stephen Julie, Plotkin Joshua B, Kudla Grzegorz

Abstract excerpt

Many organisms are subject to selective pressure that gives rise to unequal usage of synonymous codons, known as codon bias. To experimentally dissect the mechanisms of selection on synonymous sites, we expressed several hundred synonymous variants of the GFP gene in Escherichia coli, and used quantitative growth and viability assays to estimate bacterial fitness. Unexpectedly, we found many synonymous variants...

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Identifiers

PMID: 30082392
DOI: 10.1073/pnas.1810022115
PMCID: PMC6112741

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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