Correlation of translation efficiency with the decay of lacZ mRNA in Escherichia coli.

Abstract excerpt

We isolated mutations in the leader of a ribosomal protein (r-protein)/lacZ fusion gene in Escherichia coli that caused the mRNA to be translated at efficiencies between < 1% and 62% of the rate of wild-type message. Using a subset of these mutants with translation efficiencies between 5% and 62%, we studied both physical and functional decay of the mRNA after rifampicin inhibition of transcription initiation....

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