Article
Infrequent translation of a nonsense codon is sufficient to decrease mRNA level.
Molecular biology of the cell - 1 Mar 1999
Buzina A, Shulman M J
Abstract excerpt
In many organisms nonsense mutations decrease the level of mRNA. In the case of mammalian cells, it is still controversial whether translation is required for this nonsense-mediated RNA decrease (NMD). Although previous analyzes have shown that conditions that impede translation termination at nonsense codons also prevent NMD, the residual level of termination was unknown in these experiments. Moreover, the...
Topics
- Animals
- Codon, Nonsense
- Codon, Terminator
- Frameshift Mutation
- Hybridomas
- Immunoglobulin mu-Chains
- Mice
- Mutation
- Protein Biosynthesis
- RNA, Messenger