Grouping HLA-B locus serologic specificities according to shared structural motifs suggests that different peptide-anchoring pockets may have contrasting influences on the course of HIV-1 infection.

Abstract excerpt

Two different groups of HLA-B specificities were associated with two contrasting outcomes of HIV-1 infection. HLA-B45, -B49, and -B50 were each found at a moderately increased frequency among individuals responding to HIV-1 infection with a marked circulating and infiltrative CD8 T-cell lymphocytosis, a slow rate of CD4 T-cell decline, very low frequency of opportunistic infections, and low viral strain...

Topics

• AIDS-Related Opportunistic Infections
• Adult
• Antigen Presentation
• Binding Sites
• CD4 Lymphocyte Count
• CD8-Positive T-Lymphocytes
• Child
• Disease Progression
• Disease Susceptibility
• Gene Frequency