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Article

HIV control through a single nucleotide on the HLA-B locus.

Journal of virology - 1 Nov 2012

Kløverpris Henrik N, Harndahl Mikkel, Leslie Alasdair J, Carlson Jonathan M, Ismail Nasreen, van der Stok Mary, Huang Kuan-Hsiang Gary, Chen Fabian, Riddell Lynn, Steyn Dewald, Goedhals Dominique, van Vuuren Cloete, Frater John, Walker Bruce D, Carrington Mary, Ndung'u Thumbi, Buus Søren, Goulder Philip

Abstract excerpt

Genetic variation within the HLA-B locus has the strongest impact on HIV disease progression of any polymorphisms within the human genome. However, identifying the exact mechanism involved is complicated by several factors. HLA-Bw4 alleles provide ligands for NK cells and for CD8 T cells, and strong linkage disequilibrium between HLA class I alleles complicates the discrimination of individual HLA allelic effects...

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Identifiers

PMID: 22896606
DOI: 10.1128/JVI.01020-12
PMCID: PMC3486337

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Source receipt: pubmed, retrieved 7 Sept 2026.

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