Article
Impact of HLA-B*35 subtype differences on HIV disease outcome in Mexico.
AIDS (London, England) - 17 Jul 2014
Juarez-Molina Claudia I, Valenzuela-Ponce Humberto, Avila-Rios Santiago, Garrido-Rodriguez Daniela, Garcia-Tellez Thalía, Soto-Nava Maribel, Garcia-Morales Claudia, Goulder Philip, Reyes-Teran Gustavo
Abstract excerpt
HLA-B35 has consistently been associated with rapid HIV disease progression, particularly alleles of the Px group. As B35 is the most prevalent HLA-B in Mexico, we investigated HIV disease outcome in relation to HLA expression in a large cohort (n=976) of Mexicans. Contrary to the previous studies, no impact on viral load or CD4 cell count was observed in association with the B35 PY/Px groups. However, we...
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