Differences in peptide binding of DR11 and DR13 microvariants demonstrate the power of minor variation in generating DR functional diversity.

doi:10.1016/0198-8859(94)00157-l

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Article

Differences in peptide binding of DR11 and DR13 microvariants demonstrate the power of minor variation in generating DR functional diversity.

Human immunology - 1 Jun 1995

Hurley C K, Steiner N

Abstract excerpt

The influence of subtle HLA diversification on antigen binding was explored using murine L-cell transfectants expressing alleles in the DR11/DR13 family and a panel of peptides. The levels of binding among this family of DR microvariants were as diverse as the levels of binding among distantly re...

Topics

Alleles
Amino Acid Sequence
Antibodies, Monoclonal
Antigenic Variation
Cell Line
DNA, Complementary
Gene Transfer Techniques
HLA-DR Antigens
HLA-DR Serological Subtypes
Humans
Molecular Sequence Data
Mutation
Protein Binding

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