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Article

Immunoglobulin heavy chain variable region gene replacement As a mechanism for receptor revision in rheumatoid arthritis synovial tissue B lymphocytes.

The Journal of experimental medicine - 16 Oct 2000

Itoh K, Meffre E, Albesiano E, Farber A, Dines D, Stein P, Asnis S E, Furie R A, Jain R I, Chiorazzi N

Abstract excerpt

Mature B cells can alter their antibody repertoires by several mechanisms, including immunoglobulin heavy chain variable region (V(H)) replacement. This process changes the antigen combining site by replacing a portion of the original V(H)/diversity/heavy chain joining region (V(H)DJ(H)) rearrangement with a corresponding portion of a new V(H) segment. This exchange can involve cryptic heptamer-like sequences...

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Share to Gene Rearrangement, B-Lymphocyte, Heavy Chain
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 11034605
DOI: 10.1084/jem.192.8.1151
PMCID: PMC2195868

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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