Somatic mutation and CDR3 lengths of immunoglobulin kappa light chains expressed in patients with rheumatoid arthritis and in normal individuals.

doi:10.1172/JCI118129

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Article

Somatic mutation and CDR3 lengths of immunoglobulin kappa light chains expressed in patients with rheumatoid arthritis and in normal individuals.

The Journal of clinical investigation - 1 Aug 1995

Bridges S L, Lee S K, Johnson M L, Lavelle J C, Fowler P G, Koopman W J, Schroeder H W

Abstract excerpt

Immunoglobulin secretion by plasma cells infiltrating synovial membranes is a prominent feature of RA. Previous analyses of a cDNA library generated from synovium of RA patient BC revealed immunoglobulin kappa light chain transcripts with extensive somatic mutation, frequent N region addition, an...

Topics

Adult
Age Factors
Amino Acid Sequence
Arthritis, Rheumatoid
Base Sequence
Binding Sites, Antibody
Codon
DNA, Complementary
Gene Rearrangement, B-Lymphocyte, Light Chain
Genes, Immunoglobulin
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunoglobulin Variable Region

Immunoglobulin kappa-Chains

Male

Middle Aged

Molecular Sequence Data

Molecular Weight

Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 7635977
DOI: 10.1172/JCI118129
PMCID: PMC185269

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7635977-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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