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Article

A high prevalence of functional inactivation by methylation modification of p16INK4A/CDKN2/MTS1 gene in primary urothelial cancers.

Japanese journal of cancer research : Gann - 1 Nov 1997

Akao T, Kakehi Y, Itoh N, Ozdemir E, Shimizu T, Tachibana A, Sasaki M S, Yoshida O

Abstract excerpt

We analyzed the genetic and epigenetic alterations of p16INK4A/CDKN2/MTS1 gene (MTS1 gene) in 38 primary urothelial cancers. Genetic alterations of the MTS1 gene consisted of one base substitution mutation in exon 2 (2.6%) and 6 homozygous deletions (16.2%). Hypermethylation of the 5' CpG island in exon 1 of the MTS1 gene was observed in 12 tumors (37.5%). Consequently, 19 of 38 tumors (50%) showed genetic...

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Identifiers

PMID: 9439683
DOI: 10.1111/j.1349-7006.1997.tb00332.x
PMCID: PMC5921315

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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