Article
Activation but not inactivation of the MTS1 gene is associated with primary colorectal carcinomas.
Biochemical and biophysical research communications - 24 Sept 1996
Ohhara M, Esumi M, Kurosu Y
Abstract excerpt
Several investigators have reported that alterations of the multiple tumor suppressor 1 (MTS1) gene frequently occurred in certain types of tumors. We examined the expression levels and somatic mutations of the MTS1 gene in primary colorectal carcinomas. The MTS1 transcript was quantitatively detected in 14 of 17 tumors, but in only one case of adjacent normal mucosa. Direct sequencing of the amplified MTS1 gene...
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