Absence of MEN2A- or 2B-type RET mutations in primary neuroblastoma tumour tissue.

doi:10.1006/mcpr.1998.0181

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Article

Absence of MEN2A- or 2B-type RET mutations in primary neuroblastoma tumour tissue.

Molecular and cellular probes - 1 Aug 1998

Peaston A E, Camacho M L, Norris M D, Haber M, Marsh D J, Robinson B G, Hyland V J, Marshall G M

Abstract excerpt

Specific germline mutations in the RET proto-oncogene predispose to the familial cancer syndromes: multiple endocrine neoplasia (MEN) types 2A and 2B, and familial medullary thyroid carcinoma. Expression of the RET receptor tyrosine kinase is tightly restricted to tumours of neural crest origin, such as neuroblastoma, and neuroblastoma has been observed in RET transgenic mice. Neuroblastoma tumour cell lines...

Topics

DNA, Neoplasm
Drosophila Proteins
Humans
Multiple Endocrine Neoplasia Type 2a
Multiple Endocrine Neoplasia Type 2b
Mutation
Neuroblastoma
Proto-Oncogene Mas
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-ret
Receptor Protein-Tyrosine Kinases
Tumor Cells, Cultured

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PMID: 9727201
DOI: 10.1006/mcpr.1998.0181

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