Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Frequent inactivation of CDKN2A and rare mutation of TP53 in PCNSL.

Brain pathology (Zurich, Switzerland) - 1 Apr 1998

Cobbers J M, Wolter M, Reifenberger J, Ring G U, Jessen F, An H X, Niederacher D, Schmidt E E, Ichimura K, Floeth F, Kirsch L, Borchard F, Louis D N, Collins V P, Reifenberger G

Abstract excerpt

Twenty primary central nervous system lymphomas (PCNSL) from immunocompetent patients (nineteen B-cell lymphomas and one T-cell lymphoma) were investigated for genetic alterations and/or expression of the genes BCL2, CCND1, CDK4, CDKN1A, CDKN2A, MDM2, MYC, RB1, REL, and TP53. The gene found to be altered most frequently was CDKN2A. Eight tumors (40%) showed homozygous and two tumors (10%) hemizygous CDKN2A...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cyclin-Dependent Kinase Inhibitor p16
Share to Aged

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Expression Regulation

Share to Immunohistochemistry

Share to Lymphoma, B-Cell

Share to Molecular Biology

Share to Mutation

Share to Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 9546285
DOI: 10.1111/j.1750-3639.1998.tb00152.x
PMCID: PMC8098352

Genes

BCL2
CCND1
CDK4
MDM2
MYC
REL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Frequent inactivation of CDKN2A and rare mutation of TP53 in PCNSL.PMID 9546285Read ↗

Primary malignant lymphoma of the brain: frequent abnormalities and inactivation of p14 tumor suppressor gene.Semantic proximity Read ↗

Frequent alterations of the p14(ARF) and p16(INK4a) genes in primary central nervous system lymphomas.Semantic proximity Read ↗

Epigenetic silencing of multiple genes in primary CNS lymphomaSemantic proximity Read ↗

Aberrations of the p53 pathway components p53, MDM2 and CDKN2A appear independent in diffuse large B cell lymphoma.Semantic proximity Read ↗

Low frequency of the p53 gene mutations in neuroblastoma.Semantic proximity Read ↗

Molecular analysis of CDKN1C and TP53 in sporadic adrenal tumorsSemantic proximity Read ↗

Biallelic inactivation ofTP53 rarely contributes to the development of malignant peripheral nerve sheath tumorsSemantic proximity Read ↗

Aberrations of the CHK2 gene are rare in pediatric solid tumors.Semantic proximity Read ↗

Biallelic inactivation of TP53 rarely contributes to the development of malignant peripheral nerve sheath tumors.Semantic proximity Read ↗

TP53 gene mutations and CCND1 gene amplification in head and neck squamous cell carcinoma cell lines.Semantic proximity Read ↗

Type and frequency of p53 mutations in tumors of the nervous system and its coverings.Semantic proximity Read ↗

No CDKN2 mutations in neuroblastomas.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.