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Article

Frequent inactivation of CDKN2A and rare mutation of TP53 in PCNSL.

Brain pathology (Zurich, Switzerland) - 1 Apr 1998

Cobbers J M, Wolter M, Reifenberger J, Ring G U, Jessen F, An H X, Niederacher D, Schmidt E E, Ichimura K, Floeth F, Kirsch L, Borchard F, Louis D N, Collins V P, Reifenberger G

Abstract excerpt

Twenty primary central nervous system lymphomas (PCNSL) from immunocompetent patients (nineteen B-cell lymphomas and one T-cell lymphoma) were investigated for genetic alterations and/or expression of the genes BCL2, CCND1, CDK4, CDKN1A, CDKN2A, MDM2, MYC, RB1, REL, and TP53. The gene found to be...

Topics

Aged
Central Nervous System Neoplasms
Cyclin-Dependent Kinase Inhibitor p16
Female
Gene Expression Regulation
Humans
Immunohistochemistry
Lymphoma, B-Cell
Lymphoma, T-Cell
Male
Middle Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Biology

Mutation

Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 9546285
DOI: 10.1111/j.1750-3639.1998.tb00152.x
PMCID: PMC8098352

Genes

BCL2
CCND1
CDK4
MDM2
MYC
REL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9546285-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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