Article
Analysis of chromosome 9p21 deletion and p16 gene mutation in salivary gland carcinomas.
Human pathology - 1 Oct 1999
Cerilli L A, Swartzbaugh J R, Saadut R, Marshall C E, Rumpel C A, Moskaluk C A, Frierson H F
Abstract excerpt
The chromosomal locus 9p21 contains the p16(INK4a/CDKN2/MTS1) tumor suppressor gene that has been implicated in a variety of tumor types, including carcinomas of the head and neck, esophagus, and pancreas. To determine whether the loss of this gene is involved in salivary gland cancers, 35 carcinomas and paired nonneoplastic specimens were analyzed for loss of heterozygosity (LOH) of polymorphic genetic markers...
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