Article
Epigenetic inactivation of TSLC1 gene in nasopharyngeal carcinoma.
Molecular carcinogenesis - 1 Dec 2003
Hui Angela Bik-Yu, Lo Kwok-Wai, Kwong Joseph, Lam Eric Ching-Wan, Chan Sylvia Yat-Yee, Chow Lillian Shuk-Nga, Chan Andrew Siu-Chung, Teo Peter Man-Lung, Huang Dolly P
Abstract excerpt
Deletion of 11q23 is a common genetic aberration in nasopharyngeal carcinoma (NPC). Multiple candidate tumor suppressor genes (TSG) were mapped to this region but few of them were investigated in NPC. TSLC1 (tumor suppressor in lung cancer) is recently reported to be a putative TSG on 11q23. This gene was found to be inactivated by promoter hypermethylation in non-small cell lung carcinoma (NSCLC), liver cancer,...
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