Article
Alterations of the p16 gene in head and neck cancer: frequency and association with p53, PRAD-1 and HPV.
Oncogene - 20 Feb 1997
Olshan A F, Weissler M C, Pei H, Conway K, Anderson S, Fried D B, Yarbrough W G
Abstract excerpt
Alterations, especially homozygous deletions, of the putative tumor suppressor gene, p16 (p16INK4A, MTS1, CDKN2) have been found in tumor cell lines from a variety of neoplasms. Recent studies have reported frequent p16 gene deletions in cell lines from squamous cell carcinomas of the head and ne...
Topics
- Adult
- Aged
- Carcinoma, Squamous Cell
- Carrier Proteins
- Cyclin D1
- Cyclin-Dependent Kinase Inhibitor p16
- Cyclins
- Female
- Genes, Tumor Suppressor
- Genes, p53
- Head and Neck Neoplasms
- Humans
- Male
- Middle Aged
- Mutation
- Oncogene Proteins
- Papillomaviridae