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Article

Alterations of the p16 gene in head and neck cancer: frequency and association with p53, PRAD-1 and HPV.

Oncogene - 20 Feb 1997

Olshan A F, Weissler M C, Pei H, Conway K, Anderson S, Fried D B, Yarbrough W G

Abstract excerpt

Alterations, especially homozygous deletions, of the putative tumor suppressor gene, p16 (p16INK4A, MTS1, CDKN2) have been found in tumor cell lines from a variety of neoplasms. Recent studies have reported frequent p16 gene deletions in cell lines from squamous cell carcinomas of the head and neck (SCCHN), although the prevalence of alterations was variable in primary tumors. This study determined the prevalence...

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Identifiers

PMID: 9047388
DOI: 10.1038/sj.onc.1200892

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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