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Article

Methylation, a major mechanism of p16/CDKN2 gene inactivation in head and neck squamous carcinoma.

The American journal of pathology - 1 Dec 1997

El-Naggar A K, Lai S, Clayman G, Lee J K, Luna M A, Goepfert H, Batsakis J G

Abstract excerpt

We studied 11 head and neck squamous carcinoma (HNSC) cell lines and 46 primary tumors for p16 gene status by protein, mRNA, and DNA genetic/epigenetic analyses to determine the incidence, the mechanism(s), and the potential biological significance of its inactivation. Of the 11 cell lines, only 1 showed intact p16 and 10 lacked its protein and mRNA; DNA analysis of these 10 cell lines showed 2 homozygous...

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Identifiers

PMID: 9403727
PMCID: PMC1858347

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