Article
p16 mutation frequency and clinical correlation in head and neck cancer.
Acta oto-laryngologica - 1 Mar 1999
Danahey D G, Tobin E J, Schuller D E, Bier-Laning C M, Weghorst C M, Lang J C
Abstract excerpt
The tumor suppressor gene p16, when altered, has been shown to play a role in oncogenesis in many different tumor types including head and neck cancer. The goal of this study was to analyse alterations to p16 in squamous cell carcinoma (SCC) of the head and neck and to correlate these with clinical outcome. RNA was isolated from 26 SCC head and neck tumors and from 24 matched controls. A reverse transcription...
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