Article
Resistance of hippocampal synaptic transmission to hypoxia in carbonic anhydrase II-deficient mice.
Brain research - 13 Feb 1995
Velísek L, Moshé S L, Stanton P K
Abstract excerpt
Mutant Car2n/Car2n mice deficient in carbonic anhydrase II (CA II; a major brain CA isozyme) suffer from systemic acidosis and are more resistant to experimental seizures than their normal littermates (+/+ or +/Car2n). The N-methyl-D-aspartate (NMDA) subtype of glutamate receptor has been shown to contribute to long-term potentiation (LTP) of synaptic transmission, hypoxic/ischemic neuronal injury and to be...
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