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Article

Enhanced excitatory transmission at cortical synapses as the basis for facilitated spreading depression in Ca(v)2.1 knockin migraine mice.

Neuron - 12 Mar 2009

Tottene Angelita, Conti Rossella, Fabbro Alessandra, Vecchia Dania, Shapovalova Maryna, Santello Mirko, van den Maagdenberg Arn M J M, Ferrari Michel D, Pietrobon Daniela

Abstract excerpt

Migraine is a common disabling brain disorder. A subtype of migraine with aura (familial hemiplegic migraine type 1: FHM1) is caused by mutations in Ca(V)2.1 (P/Q-type) Ca(2+) channels. Knockin mice carrying a FHM1 mutation show increased neuronal P/Q-type current and facilitation of induction and propagation of cortical spreading depression (CSD), the phenomenon that underlies migraine aura and may activate...

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Identifiers

PMID: 19285472
DOI: 10.1016/j.neuron.2009.01.027

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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