Article

Inhibition of RNA splicing is a novel therapeutic strategy for disruption of nuclear replicating viruses

2026-06-27

Abstract excerpt

RNA splicing is a fundamental feature of eukaryotic gene expression that is co-opted by many nuclear-replicating viruses to produce viral transcripts. Recent clinical development of spliceosome-targeting therapeutics has demonstrated that splicing can be safely modulated in vivo, raising the possibility that viral dependence on host RNA processing may represent an exploitable antiviral vulnerability. Here, we sho...

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Literature Corpus work: 2a947a48-6cac-5563-a63c-ae4f00cc7ad4
DOI: 10.64898/2026.06.26.734849

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