Selection and characterization of replication-competent revertants of a Rous sarcoma virus src gene oversplicing mutant.

doi:10.1128/JVI.70.6.3636-3644.1996

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Article

Selection and characterization of replication-competent revertants of a Rous sarcoma virus src gene oversplicing mutant.

Journal of virology - 1 Jun 1996

Zhang L, Simpson S B, Stoltzfus C M

Abstract excerpt

All retroviruses require both unspliced and spliced RNA for a productive infection. One mechanism by which Rous sarcoma virus achieves incomplete splicing involves suboptimal env and src 3' splice sites. We have previously shown that mutagenesis of the nonconsensus src polypyrimidine tract to a 1...

Topics

Animals
Avian Sarcoma Viruses
Base Sequence
Chickens
Cloning, Molecular
Genes, src
Molecular Sequence Data
Mutation
RNA Splicing
Virus Replication

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