Article
Selection and characterization of replication-competent revertants of a Rous sarcoma virus src gene oversplicing mutant.
Journal of virology - 1 Jun 1996
Zhang L, Simpson S B, Stoltzfus C M
Abstract excerpt
All retroviruses require both unspliced and spliced RNA for a productive infection. One mechanism by which Rous sarcoma virus achieves incomplete splicing involves suboptimal env and src 3' splice sites. We have previously shown that mutagenesis of the nonconsensus src polypyrimidine tract to a 14-nucleotide uninterrupted polypyrimidine tract results in an oversplicing phenotype and a concomitant defective...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
