Mutations in the regions of the Rous sarcoma virus 3' splice sites: implications for regulation of alternative splicing.

Abstract excerpt

Retrovirus RNA is synthesized as a single primary transcript that is differentially processed by RNA splicing. Three species of viral RNA (spliced env, spliced src, and unspliced full-length RNA) are produced in chicken embryo fibroblasts infected with Rous sarcoma virus, an avian retrovirus. The env and src mRNAs are synthesized by the alternative use of two 3' splice sites. The mechanism by which balanced...

Topics

• Animals
• Avian Sarcoma Viruses
• Base Sequence
• Cells, Cultured
• Chick Embryo
• DNA, Viral
• Gene Products, env
• Gene Products, gag
• Genes, gag
• Genes, pol
• Molecular Sequence Data