Article
Determinants of target gene specificity for ROR alpha 1: monomeric DNA binding by an orphan nuclear receptor.
Molecular and cellular biology - 1 May 1995
Giguère V, McBroom L D, Flock G
Abstract excerpt
The ROR alpha isoforms are orphan members of the steroid/thyroid/retinoid receptor superfamily. Previous DNA-binding studies indicated that ROR alpha isoforms bind to response elements consisting of a single copy of the core recognition sequence AGGTCA preceded by a 6-bp A/T-rich sequence and tha...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Binding Sites
- DNA
- DNA Primers
- Models, Molecular
- Molecular Sequence Data
- Mutation
- Nucleic Acid Conformation
- Protein Binding
- Protein Conformation
- Receptors, Cytoplasmic and Nuclear
- Recombinant Fusion Proteins