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Article

A naturally occurring steroidogenic factor-1 mutation exhibits differential binding and activation of target genes.

The Journal of biological chemistry - 13 Oct 2000

Ito M, Achermann J C, Jameson J L

Abstract excerpt

Steroidogenic factor-1 (SF-1) is an orphan nuclear receptor that binds DNA as a monomer and regulates the transcription of multiple target genes. A mutation in the proximal (P)-box of the first zinc finger of SF-1 (G35E) has been reported to cause complete XY sex reversal and adrenal insufficiency. Because this P-box region dictates DNA binding specificity, we investigated the effect of this mutation on DNA...

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Source

Identifiers

PMID: 10913126
DOI: 10.1074/jbc.M002892200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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