Association of Glu 27 beta 2-adrenoceptor polymorphism with lower airway reactivity in asthmatic subjects.

doi:10.1016/s0140-6736(95)91994-5

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Article

Association of Glu 27 beta 2-adrenoceptor polymorphism with lower airway reactivity in asthmatic subjects.

Lancet (London, England) - 13 May 1995

Hall I P, Wheatley A, Wilding P, Liggett S B

Abstract excerpt

Cells expressing the Glu 27 beta 2-adrenoceptor polymorphism show attenuated down-regulation of the receptor after long-term exposure to agonist. We studied beta 2-adrenoceptor genotype for the Gln/Glu 27 polymorphism and airway reactivity in 65 patients with mild to moderate asthma. Glu 27 homoz...

Topics

Adult
Asthma
Base Sequence
Bronchial Hyperreactivity
Genotype
Humans
Methacholine Chloride
Molecular Sequence Data
Polymerase Chain Reaction
Polymorphism, Genetic
Receptors, Adrenergic, beta-2

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