Article
Beta2-adrenergic receptor polymorphisms affect airway responsiveness to salbutamol in asthmatics.
The Journal of asthma : official journal of the Association for the Care of Asthma - 1 Oct 1999
Kotani Y, Nishimura Y, Maeda H, Yokoyama M
Abstract excerpt
We examined the beta2-adrenergic receptor (beta2AR) polymorphisms (Arg16-->Gly, Gln27-->Glu) and clinical status for 117 asthmatics. Airway responsiveness to methacholine and beta2-agonists was evaluated with Astograph. The atopic factors, pulmonary function test, and airway responsiveness to methacholine did not differ significantly among the different beta2AR genotypes. Asthmatics homozygous for Gly16 showed...
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