Article
Polymorphisms of the beta2-adrenergic receptor and asthma.
American journal of respiratory and critical care medicine - 1 Oct 1997
Liggett S B
Abstract excerpt
Several missense mutations (polymorphisms) within the coding block of the beta-adrenergic receptor (beta2AR) gene on chromosome 5q31 have been identified in the human population. In studies utilizing site-directed mutagenesis and recombinant expression, three loci at amino acid positions 16, 27, and 164 have been found to significantly alter receptor function. The Ile164 form displays altered coupling to adenylyl...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
