Article
Liver p53 expression in patients with HCV-related chronic hepatitis.
Journal of viral hepatitis - 1 Jul 2003
Loguercio C, Cuomo A, Tuccillo C, Gazzerro P, Cioffi M, Molinari A M, Del Vecchio Blanco C
Abstract excerpt
Mutated p53 acts as a dominant oncogene and alterations in the p53 gene are described in a large number of patients with hepatocellular carcinoma (HCC). It has been demonstrated that hepatitis C virus (HCV)-core protein regulates transcriptionally cellular genes, as well as cell growth and apoptosis. This study was undertaken to evaluate whether p53 may be expressed also in a precocious stage of HCV-related liver...
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