Article
Effects of an Rb mutation in the mouse.
Nature - 24 Sept 1992
Jacks T, Fazeli A, Schmitt E M, Bronson R T, Goodell M A, Weinberg R A
Abstract excerpt
The retinoblastoma gene is mutated in several types of human cancer and is the best characterized of the tumour-suppressor genes. A mouse strain has been constructed in which one allele of Rb is disrupted. These heterozygous animals are not predisposed to retinoblastoma, but some display pituitar...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Cell Death
- Erythropoiesis
- Eye Neoplasms
- Genes, Retinoblastoma
- Heterozygote
- Homozygote
- Humans
- Liver
- Mice
- Mice, Mutant Strains
- Molecular Sequence Data
- Mutation
- Neurons
- Phenotype
- Restriction Mapping