Article
Effects of an Rb mutation in the mouse.
Nature - 24 Sept 1992
Jacks T, Fazeli A, Schmitt E M, Bronson R T, Goodell M A, Weinberg R A
Abstract excerpt
The retinoblastoma gene is mutated in several types of human cancer and is the best characterized of the tumour-suppressor genes. A mouse strain has been constructed in which one allele of Rb is disrupted. These heterozygous animals are not predisposed to retinoblastoma, but some display pituitary tumours arising from cells in which the wild-type Rb allele is absent. Embryos homozygous for the mutation die...
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