Article
Lack of augmentation of tumor spectrum or severity in dual heterozygous Men1 and Rb1 knockout mice.
Oncogene - 7 Jun 2007
Loffler K A, Biondi C A, Gartside M G, Serewko-Auret M M, Duncan R, Tonks I D, Mould A W, Waring P, Muller H K, Kay G F, Hayward N K
Abstract excerpt
To identify possible genetic interactions between the mechanisms of tumor suppression of menin and pRb, we intercrossed mice with targeted deletions of Men1 and Rb1, and compared tumor development in cohorts of animals carrying single or dual mutations of these tumor-suppressor genes. In mice lacking one copy of Men1, pancreatic islet and anterior pituitary adenomas are common. In animals lacking one copy of Rb1,...
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