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Familial isolated pituitary adenoma is independent of Ahr genotype in a novel mouse model of disease

26 Mar 2024

Abstract excerpt

Human familial isolated pituitary adenoma (FIPA) has been linked to germline heterozygous mutations in the gene encoding the aryl hydrocarbon receptor-interacting protein (AIP, also known as ARA9, XAP2, FKBP16, or FKBP37). To investigate the hypothesis that AIP is a pituitary adenoma tumor suppressor via its role in aryl hydrocarbon receptor (AHR) signaling, we have compared the pituitary phenotype of our global...

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PMID: 38590848
DOI: 10.1016/j.heliyon.2024.e28231

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