Article
Tumour predisposition in mice heterozygous for a targeted mutation in Nf1.
Nature genetics - 1 Jul 1994
Jacks T, Shih T S, Schmitt E M, Bronson R T, Bernards A, Weinberg R A
Abstract excerpt
Human neurofibromatosis type 1 is a dominant disease caused by the inheritance of a mutant allele of the NF1 gene. In order to study NF1 function, we have constructed a mouse strain carrying a germline mutation in the murine homologue. Heterozygous animals do not exhibit the classical symptoms of the human disease, but are highly predisposed to the formation of various tumour types, notably phaeochomocytoma, a...
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