Tumour predisposition in mice heterozygous for a targeted mutation in Nf1.

doi:10.1038/ng0794-353

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Article

Tumour predisposition in mice heterozygous for a targeted mutation in Nf1.

Nature genetics - 1 Jul 1994

Jacks T, Shih T S, Schmitt E M, Bronson R T, Bernards A, Weinberg R A

Abstract excerpt

Human neurofibromatosis type 1 is a dominant disease caused by the inheritance of a mutant allele of the NF1 gene. In order to study NF1 function, we have constructed a mouse strain carrying a germline mutation in the murine homologue. Heterozygous animals do not exhibit the classical symptoms of...

Topics

Adrenal Gland Neoplasms
Alleles
Animals
Base Sequence
Disease Models, Animal
Fetal Death
Genes, Lethal
Genes, Neurofibromatosis 1
Genes, Synthetic
Genetic Predisposition to Disease
Heart Defects, Congenital
Heterozygote
Humans
Leukemia, Myeloid
Mice
Mice, Knockout
Mice, Mutant Strains
Molecular Sequence Data

Source

Open in PubMed

Identifiers

PMID: 7920653
DOI: 10.1038/ng0794-353

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7920653-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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