Inbreeding abolishes the effect of parental origin of a mutant Rb-1 allele on pituitary tumorigenesis in mice.

Abstract excerpt

The previously reported earlier onset of pituitary tumours in cross-bred mice inheriting a mutant Rb-1 allele paternally has been ascribed to imprinting of an Rb-1-linked gene. Here, we demonstrate that, as predicted from this mechanism, there is no effect of the parent of origin of the mutation in inbred mice.

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Inbreeding
• Share to Mice
• Share to Mice, Mutant Strains