Article
Evaluation of steroid receptor function by gene targeting in mice.
The Journal of steroid biochemistry and molecular biology - 1 Feb 2005
Wintermantel Tim M, Berger Stefan, Greiner Erich F, Schütz Günther
Abstract excerpt
Corticosteroid hormones regulate a variety of developmental, physiological and pathological processes via their cognate receptors, the glucocorticoid receptor (GR) and the mineralocorticoid receptor (MR). Using modern genetic technologies, including bacterial artificial chromosome-based transgenesis and conditional gene targeting, we have generated a panel of tissue-specific and function-selective mutations of...
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