Article
Altered subcellular location of an activated and tumour-associated epidermal growth factor receptor.
Oncogene - 6 Apr 1995
Ekstrand A J, Liu L, He J, Hamid M L, Longo N, Collins V P, James C D
Abstract excerpt
The epidermal growth factor (EGF) receptor is a membrane bound tyrosine kinase whose activity is initiated by ligand binding. The malignant brain tumour glioblastoma frequently shows amplification and rearrangements of the EGF receptor gene that are associated with the synthesis of a constitutive...
Topics
- Animals
- CHO Cells
- Cell Compartmentation
- Cell Membrane
- Cricetinae
- Cytoplasm
- Epidermal Growth Factor
- ErbB Receptors
- Fluorescent Antibody Technique
- Glioblastoma
- Hexosaminidases
- Mutation
- Transfection