Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Interaction of Hsp90 with the nascent form of the mutant epidermal growth factor receptor EGFRvIII.

The Journal of biological chemistry - 14 Feb 2003

Lavictoire Sylvie J, Parolin Doris A E, Klimowicz Alex C, Kelly John F, Lorimer Ian A J

Abstract excerpt

EGFRvIII is a mutant epidermal growth factor that promotes aggressive growth of glioblastomas. We made a plasmid that directed the expression of an EGFRvIII with three copies of the Flag epitope at its amino terminus. Flag-tagged EGFRvIII was expressed at the same levels as unmodified EGFRvIII, and showed the same subcellular localization. However, the Flag epitope could only be detected on EGFRvIII present in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Cycle Proteins
Share to Chaperonins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drosophila Proteins

Share to Endoplasmic Reticulum

Share to ErbB Receptors

Share to HSP90 Heat-Shock Proteins

Share to Molecular Chaperones

Share to Protein Binding

Source

Identifiers

PMID: 12471035
DOI: 10.1074/jbc.M209494200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Interaction of Hsp90 with the nascent form of the mutant epidermal growth factor receptor EGFRvIII.PMID 12471035Read ↗

The EGFR variant III mutant as a target for immunotherapy of glioblastoma multiforme.Semantic proximity Read ↗

Mutant epidermal growth factor receptors as targets for cancer therapy.Semantic proximity Read ↗

Cell line with endogenous EGFRvIII expression is a suitable model for research and drug development purposes.Semantic proximity Read ↗

The epidermal growth factor receptor variant <scp>III</scp> (<scp>EGFR</scp>v<scp>III</scp>): where wild things are alteredSemantic proximity Read ↗

Expression of EGFRvIII in Glioblastoma: Prognostic Significance RevisitedSemantic proximity Read ↗

The deletion mutant EGFRvIII significantly contributes to stress resistance typical for the tumour microenvironment.Semantic proximity Read ↗

Oncogenic mutant forms of EGFR: lessons in signal transduction and targets for cancer therapy.Semantic proximity Read ↗

High Affinity Chimeric Antigen Receptor with Cross-Reactive scFv to Clinically Relevant EGFR Oncogenic IsoformsSemantic proximity Read ↗

Development of an EGFRvIII specific recombinant antibodySemantic proximity Read ↗

EGFR phosphorylates tumor-derived EGFRvIII driving STAT3/5 and progression in glioblastoma.Semantic proximity Read ↗

F25P preproinsulin abrogates the secretion of pro-growth factors from EGFRvIII cells and suppresses tumor growth in an EGFRvIII/wt heterogenic model.Semantic proximity Read ↗

Targeting EGF receptor variant III: tumor-specific peptide vaccination for malignant gliomasSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.