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Article

Structural analysis of the transmembrane domain of the epidermal growth factor receptor.

The Journal of biological chemistry - 25 Mar 1991

Carpenter C D, Ingraham H A, Cochet C, Walton G M, Lazar C S, Sowadski J M, Rosenfeld M G, Gill G N

Abstract excerpt

The ligand-binding domain of the epidermal growth factor (EGF) receptor is separated from the cytoplasmic protein tyrosine kinase domain by a predicted single transmembrane segment. Antipeptide antibodies prepared against the outer portion of the predicted transmembrane segment confirmed this area was exposed only when cells were treated with permeabilizing agents. To investigate structural requirements for...

Topics

Amino Acid Sequence
Animals
Cricetinae
Cricetulus
Electrophoresis, Polyacrylamide Gel
ErbB Receptors
Humans
Immunoglobulin G
Mice
Molecular Sequence Data
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein-Tyrosine Kinases

Source

Identifiers

PMID: 2005111

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2005111-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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