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Article

Mutagenicity of a unique 8-oxoguanine in a human Ha-ras sequence in mammalian cells.

Carcinogenesis - 1 Nov 1995

Le Page F, Margot A, Grollman A P, Sarasin A, Gentil A

Abstract excerpt

The processing of a unique 8-oxoguanine residue in DNA has been studied in mammalian cells using a single-stranded shuttle vector. A fragment of human Ha-ras carrying the lesion on the first (G1) or the second guanine (G2) of codon 12 was inserted in a shuttle plasmid. Extrachromosomal DNA is replicated in animal cells, extracted and used to transform bacteria to be amplified and individualized. DNA sequencing of...

Topics

Animals
Base Sequence
Cells, Cultured
Genes, ras
Guanine
Haplorhini
Humans
Molecular Sequence Data
Mutagens
Mutation

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 7586199
DOI: 10.1093/carcin/16.11.2779

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7586199-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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