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Article

Mutagenicity of a unique 8-oxoguanine in a human Ha-ras sequence in mammalian cells.

Carcinogenesis - 1 Nov 1995

Le Page F, Margot A, Grollman A P, Sarasin A, Gentil A

Abstract excerpt

The processing of a unique 8-oxoguanine residue in DNA has been studied in mammalian cells using a single-stranded shuttle vector. A fragment of human Ha-ras carrying the lesion on the first (G1) or the second guanine (G2) of codon 12 was inserted in a shuttle plasmid. Extrachromosomal DNA is replicated in animal cells, extracted and used to transform bacteria to be amplified and individualized. DNA sequencing of...

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Identifiers

PMID: 7586199
DOI: 10.1093/carcin/16.11.2779

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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