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Article

Correlation of (6-4)photoproduct formation with transforming mutations in UV-irradiated Ha-ras.

Carcinogenesis - 1 Apr 1995

Yagi T, Morimoto T, Takebe H

Abstract excerpt

Sites and types of mutations in relation to the amount of cyclobutane pyrimidine dimers (CPDs) and (6-4)-photoproducts in UV-irradiated normal Ha-ras sequences were investigated. Mouse BALB/C 3T3 cells were transfected with UV-irradiated pYN-mHras plasmids containing mouse normal Ha-ras sequences, and transformed foci developed. Direct DNA sequencing of the Ha-ras retrieved from the foci revealed that most...

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PMID: 7728944
DOI: 10.1093/carcin/16.4.689

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