Article
Role of chromosome 9 in human bladder cancer.
Cancer research - 1 Sept 1993
Miyao N, Tsai Y C, Lerner S P, Olumi A F, Spruck C H, Gonzalez-Zulueta M, Nichols P W, Skinner D G, Jones P A
Abstract excerpt
The tumors of 20 patients with multifocal primary transitional cell carcinoma of the bladder or lymph node metastases were examined for molecular genetic defects which we have previously found to be present in > 50% of invasive tumors. These included loss of heterozygosity (LOH) of chromosome 9, which occurs in superficial as well as invasive bladder tumors, and LOH of chromosome 17p and p53 mutations, which are...
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