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Article

N-Glycosylation affects endoplasmic reticulum degradation of a mutated derivative of carboxypeptidase yscY in yeast.

Yeast (Chichester, England) - 30 Sept 1996

Knop M, Hauser N, Wolf D H

Abstract excerpt

The endoplasmic reticulum (ER) of eukaryotic cells contains a quality control system, that is required for the proteolytic removal of aberrantly folded proteins that accumulate in this organelle. We used genetic and biochemical methods to analyse the involvement of N-glycosylation in the degradation of a mutant derivative of carboxypeptidase yscY in the ER of the yeast Saccharomyces cerevisiae. Our results...

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PMID: 8905927
DOI: 10.1002/(sici)1097-0061(19960930)12:12<1229::aid-yea15>3.0.co;2-h

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Source receipt: pubmed, retrieved 7 Sept 2026.

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N-Glycosylation affects endoplasmic reticulum degradation of a mutated derivative of carboxypeptidase yscY in yeast.PMID 8905927Read ↗

Multiple endoplasmic reticulum-associated pathways degrade mutant yeast carboxypeptidase Y in mammalian cells.Semantic proximity Read ↗

Cytoplasmic peptide:N-glycanase cleaves N-glycans on a carboxypeptidase Y mutant during ERAD in Saccharomyces cerevisiae.Semantic proximity Read ↗

Yeast carboxypeptidase Y requires glycosylation for efficient intracellular transport, but not for vacuolar sorting, in vivo stability, or activity.Semantic proximity Read ↗

Analysis of two mutated vacuolar proteins reveals a degradation pathway in the endoplasmic reticulum or a related compartment of yeast.Semantic proximity Read ↗

ER-golgi traffic is a prerequisite for efficient ER degradation.Semantic proximity Read ↗

Unstable mutant lysozymes are degraded through the interaction with calnexin homolog Cne1p in Saccharomyces cerevisiae.Semantic proximity Read ↗

Stress tolerance of misfolded carboxypeptidase Y requires maintenance of protein trafficking and degradative pathways.Semantic proximity Read ↗

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Proteolytic processing of a secreted glycoprotein and O-glycosylation of mannoproteins are affected in the N-glycosylation mutant Saccharomyces cerevisiae ldb1.Semantic proximity Read ↗

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