N-Glycosylation affects endoplasmic reticulum degradation of a mutated derivative of carboxypeptidase yscY in yeast.

doi:10.1002/(sici)1097-0061(19960930)12:12<1229::aid-yea15>3.0.co;2-h

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Article

N-Glycosylation affects endoplasmic reticulum degradation of a mutated derivative of carboxypeptidase yscY in yeast.

Yeast (Chichester, England) - 30 Sept 1996

Knop M, Hauser N, Wolf D H

Abstract excerpt

The endoplasmic reticulum (ER) of eukaryotic cells contains a quality control system, that is required for the proteolytic removal of aberrantly folded proteins that accumulate in this organelle. We used genetic and biochemical methods to analyse the involvement of N-glycosylation in the degradat...

Topics

Calcium-Binding Proteins
Calnexin
Carboxypeptidases
Cathepsin A
Endoplasmic Reticulum
Enzyme Stability
Gene Deletion
Glycosylation
Mannosidases
Mutation
Protein Folding
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins

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