Cytoplasmic peptide:N-glycanase cleaves N-glycans on a carboxypeptidase Y mutant during ERAD in Saccharomyces cerevisiae.

doi:10.1016/j.bbagen.2014.12.008

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Article

Cytoplasmic peptide:N-glycanase cleaves N-glycans on a carboxypeptidase Y mutant during ERAD in Saccharomyces cerevisiae.

Biochimica et biophysica acta - 1 Apr 2015

Hosomi Akira, Suzuki Tadashi

Abstract excerpt

BACKGROUND: Endoplasmic reticulum (ER)-associated degradation (ERAD) is a pathway by which misfolded or improperly assembled proteins in the ER are directed to degradation. The cytoplasmic peptide:N-glycanase (PNGase) is a deglycosylating enzyme that cleaves N-glycans from misfolded glycoproteins during the ERAD process. The mutant form of yeast carboxypeptidase Y (CPY*) is an ERAD model substrate that has been...

Topics

Cathepsin A
Cytoplasm
Endoplasmic Reticulum-Associated Degradation
Glycosylation
Mutation
Peptide-N4-(N-acetyl-beta-glucosaminyl) Asparagine Amidase
Polysaccharides
Proteasome Endopeptidase Complex
Saccharomyces cerevisiae

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PMID: 25497214
DOI: 10.1016/j.bbagen.2014.12.008

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