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Article

Ras membrane targeting is essential for glucose signaling but not for viability in yeast.

Proceedings of the National Academy of Sciences of the United States of America - 28 Mar 1995

Bhattacharya S, Chen L, Broach J R, Powers S

Abstract excerpt

Ras proteins are small GTP binding proteins that serve as critical relays in a variety of signal transduction pathways in eukaryotic cells. Like most metazoan Ras proteins, yeast Ras is post-translationally modified by addition of a farnesyl and a palmitoyl moiety, and these modifications are required for targeting the protein to the cytoplasmic face of the plasma membrane and for biological activity of the...

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Identifiers

PMID: 7708760
DOI: 10.1073/pnas.92.7.2984
PMCID: PMC42343

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