Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Apolipoprotein E genotyping methods for the clinical laboratory.

Journal of clinical laboratory analysis - 1 Jan 1995

Maekawa B, Cole T G, Seip R L, Bylund D

Abstract excerpt

To select the best method for detecting apolipoprotein E (apo E) genotypes determined by the three common alleles epsilon 2, epsilon 3 and epsilon 4, we compared the radiolabeled allele-specific oligonucleotide (ASO) probe assay and the nonisotopic restriction isotyping assay. Leukocytic DNA was extracted from the blood of 93 patients after which the region containing two mutation points coding amino acid...

Topics

Adolescent
Adult
Aged
Aged, 80 and over
Apolipoproteins E
Base Sequence
Female
Genotype
Humans
Leukocytes
Male
Middle Aged
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Oligonucleotide Probes

Polymerase Chain Reaction

Restriction Mapping

Source

Identifiers

PMID: 7722775
DOI: 10.1002/jcla.1860090112

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7722775-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Apolipoprotein E genotyping methods for the clinical laboratory.PMID 7722775Read ↗

Apolipoprotein E2/E3/E4 genotyping with agarose gels.Semantic proximity Read ↗

Rapid identification of the common apo E isoform genotype using polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP).Semantic proximity Read ↗

Apolipoprotein E polymorphism determined by restriction enzyme analysis of DNA amplified by polymerase chain reaction: convenient alternative to phenotyping by isoelectric focusing.Semantic proximity Read ↗

Analysis of apolipoprotein E genotypes by the Amplification Refractory Mutation System.Semantic proximity Read ↗

Common and rare genotypes of human apolipoprotein E determined by specific restriction profiles of polymerase chain reaction-amplified DNA.Semantic proximity Read ↗

Estimation of the frequency of isoform-genotype discrepancies at the apolipoprotein E locus in heterozygotes for the isoforms.Semantic proximity Read ↗

Apolipoprotein E genotyping using the polymerase chain reaction and allele-specific oligonucleotide primers.Semantic proximity Read ↗

Detection of apolipoprotein E polymorphisms using PCR/ASO probes and Southern transfer: application for routine use.Semantic proximity Read ↗

[Genotyping of apolipoprotein E (alleles epsilon 2, epsilon 3 and epsilon 4) from capillary blood].Semantic proximity Read ↗

Determination of apolipoprotein E genotypes by single-strand conformational polymorphism.Semantic proximity Read ↗

Disparity between apolipoprotein E phenotypes and genotypes (as determined by polymerase chain reaction and oligonucleotide probes) in patients with non-insulin-dependent diabetes mellitus.Semantic proximity Read ↗

Apolipoprotein E phenotypes and genotypes as determined by polymerase chain reaction using allele-specific oligonucleotide probes and the amplification refractory mutation system in children with insulin-dependent diabetes mellitus.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.