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Article

Apolipoprotein E genotyping using the polymerase chain reaction and allele-specific oligonucleotide primers.

Journal of lipid research - 1 Jan 1991

Main B F, Jones P J, MacGillivray R T, Banfield D K

Abstract excerpt

A method for apolipoprotein (apo) E genotyping was developed using the polymerase chain reaction (PCR) with allele-specific oligonucleotide primers (ASP). Synthetic oligonucleotides with base-pair mismatches at the 3' terminus were used as primers to amplify the apoE gene in subjects previously phenotyped using isoelectric focusing (IEF). Complementary primer-allele combinations were specifically amplified by...

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PMID: 2010690

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