Article
Determination of apolipoprotein E genotypes by single-strand conformational polymorphism.
Clinical chemistry - 1 Oct 1993
Tsai M Y, Suess P, Schwichtenberg K, Eckfeldt J H, Yuan J, Tuchman M, Hunninghake D
Abstract excerpt
We used single-strand conformational polymorphism (SSCP) to determine apolipoprotein E (Apo E) genotypes in 47 individuals. A 295-base-pair (bp) DNA fragment coding for amino acid residues 80-178 of the Apo E protein gave distinct patterns for the three alleles. When we used SSCP to determine the Apo E polymorphism of five individuals whose phenotyping results differed from those of genotyping, the SSCP results...
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