Article
Common and rare genotypes of human apolipoprotein E determined by specific restriction profiles of polymerase chain reaction-amplified DNA.
Clinical chemistry - 1 Jan 1994
Richard P, Thomas G, de Zulueta M P, De Gennes J L, Thomas M, Cassaigne A, Béréziat G, Iron A
Abstract excerpt
The three common isoforms of human apolipoprotein E (apo E) differ at positions 112 and 158 and are named E3, E4, and E2 according to phenotyping by isoelectric focusing (IEF). The polymerase chain reaction (PCR) method allows the detection of common and several rare allelic apo E variants not detected by IEF. We propose a genotyping procedure for apo E that characterizes a given allele on the basis of...
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